UW Genetics investigators employed data produced by the lipidomics services of the Mass Spectrometry Core Facility played an important part in the new understanding of the role of transmembrane protein 135 (TMEM135) in lipid homeostasis. The figure below shows how lipid profiles from wild-type (WT), TMEM135 overexpressing transgenic (TG), and TMEM135 mutant (FUN025) mice, cluster by principle-component analysis in liver, retina, heart, and plasma. This work was featured in the recent Communications Biology – Nature article “Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism”, by Michael Landowski and co-authors from the Akihiro Ikeda lab at UW Madison.
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